Vascular Endothelial Growth Factor, Pigment Epithelium-derived Factor, and Renal Function Determinants in Type 2 Diabetics in Kaduna, Northern Nigeria: A Case–Control Study

Authors

  • Paulinus Jimmy Unung Department of Pathology, National Eye Centre, Kaduna, Nigeria
  • Iya Eze Bassey Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria
  • Mahmoud B Alhassan Department of Retinal Medicine, National Eye Centre, Kaduna, Nigeria
  • Euphoria C. Akwiwu Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria
  • Faith A. Effa Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria
  • Maisie Henrietta Etukudo Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria
  • Alphonsus Ekpe Udoh Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria

DOI:

https://doi.org/10.7324/jhsr.2021.624

Keywords:

Type 2 Diabetes mellitus, renal function, Type 2 Diabvascular endothelial growth factor, pigment epithelium-derived factor

Abstract

Context: the role of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) on renal function of diabetics is unclear.

Objective: This study investigated the relationship between VEGF, PEDF and urea, creatinine and estimated glomerular filtration rate (eGFR) in type 2 diabetics.

Materials and Methods: 100 type 2 diabetics and 50 controls were recruited into this case-control study. Analytes were determined by standard methods. Statistical significance was set at p<0.05 and 95% Confidence interval.

 

Results: VEGF, PEDF (p=0.0001), urea (p=0.024) and creatinine (p=0.026) were significantly higher in diabetics than controls but eGFR was comparable (p>0.05) in both groups. VEGF and PEDF were comparable (p>0.05) in the diabetics with eGFR<60 ml/min and >60 ml/min. Renal function parameters did not correlate with either VEGF or PEDF.

Conclusion: plasma VEGF and PEDF are higher in diabetics but there seem to be no association between renal function determinants and either VEGF and PEDF.

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Published

2021-09-19
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How to Cite

1.
Unung PJ, Bassey IE, Alhassan MB, Akwiwu EC, Effa FA, Etukudo MH, Udoh AE. Vascular Endothelial Growth Factor, Pigment Epithelium-derived Factor, and Renal Function Determinants in Type 2 Diabetics in Kaduna, Northern Nigeria: A Case–Control Study. J Health Sci Res [Internet]. 2021Sep.19 [cited 2023Feb.22];6(2):27-34. Available from: https://jhsronline.com/index.php/jhsr/article/view/82

Issue

Volume 6, Issue 2, 2021

Section

Original Articles

Copyright (c) 2021 Paulinus Jimmy Unung, Iya Eze Bassey, Mahmoud B Alhassan, Euphoria C. Akwiwu, Faith A. Effa, Maisie Henrietta Etukudo, Alphonsus Ekpe Udoh

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This work is licensed under a Creative Commons Attribution 4.0 International License.