Relation of Serum Adenosine Deaminase to Some Risk Factors in Type 2 Diabetes Mellitus

Authors

  • Shashikala Magadi Dasegowda Diacon Hospital Bangalore, 19th main road, 1st block, Rajajinagar, Bangalore - 560010, Karnataka
  • Ashok Kumar Jeppu Department of Biochemistry, International Medical School, Management and Science University, University Drive, Off Persiaran Olahraga, Sekysen 13, Shah Alam - 40100, Selangor, Darul Ehsan
  • Sushith Department of Biochemistry, A J Institute of Medical Sciences, Kuntinana, Mangalore - 575004, Karnataka
  • Kavitha Ashok Kumar Department of Otolaryngology, International Medical School, Management and Science University, University Drive, Off Persiaran Olahraga, Sekysen 13, Shah Alam - 40100, Selangor, Darul Ehsan

DOI:

https://doi.org/10.18311/jhsr/2016/v1/i1/4726

Keywords:

Adenosine Deaminase, Diabetes Mellitus Type 2, Glycated Haemoglobin.

Abstract

Aim: Study was conducted to compare and correlate the levels of serum adenosine deaminase and serum uric acid with Fasting Plasmaglucose (FPG), Post Prandial Blood Sugar (PPBS) and glycated hemoglobin in type 2 diabetes mellitus.

Materials and Method: Study group consisted of 60 diabetics and 50 age and sex matched healthy individuals. Blood sample was collected in fasting state and two hours after the food for estimation of serum Adenosine Deaminase (ADA), uric acid, parameters of lipid profile, fasting and postprandial glucose.

Result: An increased level of serum ADA, FPG, PPBS, parameters of lipid profile and glycated haemoglobin in type 2 diabetes mellitus compared to controls. A statistically significant correlation was seen between serum ADA as well as serum uric acid with, Fasting Plasma Glucose (FPG), Post Prandial Blood Glucose (PPBS), glycated haemoglobin. Serum ADA had shown significant correlation with the Triglyceride (TG), Total Cholesterol (TC), Low Density Cholesterol (LDL cholesterol). A negative correlation was seen between serum ADA acid and High Density Lipoprotein cholesterol (HDL cholesterol).

Conclusion: Adenosine deaminase and serum uric acid levels increased and positively correlated with parameters of lipid profile and glycemic control. This indicates that ADA and serum uric acid can serve as predictor of glycaemic index and help to monitor the long term effects of diabetes mellitus.

Downloads

Download data is not yet available.

Published

2016-06-24
Statistics
26 Views | 45 Downloads
Citatons

How to Cite

1.
Dasegowda SM, Jeppu AK, Sushith, Ashok Kumar K. Relation of Serum Adenosine Deaminase to Some Risk Factors in Type 2 Diabetes Mellitus. J Health Sci Res [Internet]. 2016Jun.24 [cited 2023Feb.22];1(1):13-7. Available from: https://jhsronline.com/index.php/jhsr/article/view/7

Issue

Volume 1, Issue 1, 2016

Section

Original Articles

Copyright (c) 2016 Shashikala Magadi Dasegowda, Ashok Kumar Jeppu, Sushith, Kavitha Ashok Kumar

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.