Estimation of Toxicity Level of Three Different Herbal Bitters (Confam, G. Winco and 1960 Roots) on some Serum Lipid Profile Parameters and the Heart of Wister Albino Rats

Abstract

The aim of this research is to estimate the toxicity level of three different herbal bitters (Confam, G. Winco and 1960 Roots) on some serum lipid profile parameters and the heart of Wister albino rats. A total of 40 rats were randomly divided into 4 groups labeled A, B, C and D and kept in a well ventilated room. Group A served as control and these rats were treated with distilled water. Rats in the groups B, C, and D were treated with 3 different doses of the bitters (20, 30 and 40mL/Kgbw) respectively. The drugs were administered once daily for 10 and 21 days consecutively. Animals were sacrificed 24 hours after the last treatment. Blood samples were collected into heparinized sample bottles for analysis. There was no significant difference in the results obtained. There was dose dependent decrease in serum triglyceride and cholesterol levels. Pathological changes were seen on histology at the highest concentrations and longest durations of the herbal bitters. This study thus shows that high amounts of herbal bitters are lipid lowering and have a direct negative effect on myocardial tissue.